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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Cdc14 Antibody   

Cdc14 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Cdc14 Antibody AP8440a
    His6-cdc14 Antibody (Cat. #AP8440a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the cdc14 antibody detected the cdc14 protein (arrow).
  • IHC-P - Cdc14 Antibody AP8440a
    Cdc14 Antibody (Cat. #AP8440a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Cdc14 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - Cdc14 Antibody AP8440a
    Cdc14 Antibody (Cat. #AP8440a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNH5
Other Accession NP_003663
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 66574 Da
Additional Information
Gene ID 8556
Other Names Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A
Target/Specificity This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~379 of human cdc14.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCdc14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC14A
Function Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.


Kaiser,B.K., et al. Mol. Biol. Cell 13 (7), 2289-2300 (2002)
Mailand,N., et al. Nat. Cell Biol. 4 (4), 317-322 (2002)
Bembenek,J. and Yu,H. J. Biol. Chem. 276 (51), 48237-48242 (2001)
Li,L., et al. J. Biol. Chem. 275 (4), 2410-2414 (2000)
Wong,A.K., et al. Genomics 59 (2), 248-251 (1999)
Li,L., et al. J. Biol. Chem. 272 (47), 29403-29406 (1997)

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$ 295.00
$ 99.00
Cat# AP8440a
(40 western blots)
Availability: In Stock
Bulk Size
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