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DUSP6 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • IF - DUSP6 Antibody (Center) AP8449a
    Confocal immunofluorescent analysis of DUSP6 Antibody (Center) (Cat#AP8449a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • WB - DUSP6 Antibody (Center) AP8449a
    The anti-DUSP6 Pab (Cat. #AP8449a) is used in Western blot to detect DUSP6 in HeLa cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16828
Other Accession Q2KJ36, NP_001937
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42320 Da
Antigen Region 58-89 aa
Additional Information
Gene ID 1848
Other Names Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1
Target/Specificity This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6.
Dilution IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUSP6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP6
Synonyms MKP3, PYST1
Function Inactivates MAP kinases. Has a specificity for the ERK family.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.


Mod. Pathol. 18 (8), 1034-1042 (2005)
J. Hum. Genet. 50 (4), 159-167 (2005)
J. Biol. Chem. 279 (40), 41882-41891 (2004)
Biochemistry 42 (51), 15197-15207 (2003)
J. Biol. Chem. 271 (8), 4319-4326 (1996)

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$ 295.00
$ 99.00
Cat# AP8449a
(40 western blots)
Availability: In Stock
Bulk Size
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