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DUSP6 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8449a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
DUSP6 Antibody (Center) - Product info | |
| Application | IF
|
| Primary Accession | Q16828 |
| Other Accession | NP_001937 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 42320 Da |
DUSP6 Antibody (Center) - Additional info | |
| Gene ID 1848 | |
| Other Names DUSP6; MKP3; PYST1; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3 | |
| Target/Specificity This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67~96 amino acids from the central region of human DUSP6. | |
| Dilution IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions DUSP6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
DUSP6 Antibody (Center) - Protein Information | |
| Name DUSP6 | |
| Synonyms MKP3, PYST1 | |
| Function Inactivates MAP kinases. Has a specificity for the ERK family | |
| Cellular Location Cytoplasm. | |
DUSP6 Antibody (Center) - Related products
AP17558a: DUSP6 Antibody (N-term)
AP8449a: DUSP6 Antibody (Center)
RI11635: DUSP6 predesign siRNA
DC01258: Human DUSP6 cDNA Clone
LY11170a: DUSP6 Over-expression Lysate
BP8449a: DUSP6 Antibody (Center) Blocking Peptide
DUSP6 Antibody (Center) - Application data
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Confocal immunofluorescent analysis of DUSP6 Antibody (Center) (Cat#AP8449a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
DUSP6 Antibody (Center) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.
REFERENCES
Mod. Pathol. 18 (8), 1034-1042 (2005) J. Hum. Genet. 50 (4), 159-167 (2005) J. Biol. Chem. 279 (40), 41882-41891 (2004) Biochemistry 42 (51), 15197-15207 (2003) J. Biol. Chem. 271 (8), 4319-4326 (1996)
