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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DUSP10 Antibody (N-term)   

DUSP10 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DUSP10 Antibody (N-term) AP8453a
    Anti-DUSP10 Antibody (N-term) at 1:1000 dilution + RD whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - DUSP10 Antibody (N-term) AP8453a
    Western blot analysis of anti-DUSP10 Pab (Cat. #AP8453a) in mouse heart tissue lysates (35ug/lane). DUSP10(arrow) was detected using the purified Pab.
  • IHC-P - DUSP10 Antibody (N-term) AP8453a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • IHC-P - DUSP10 Antibody (N-term) AP8453a
    Formalin-fixed and paraffin-embedded human testis tissue reacted with DUSP10 Antibody (N-term) (Cat.#AP8453a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6W6
Other Accession Q9ESS0, Q0IID7
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52642 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 11221
Other Names Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MAP kinase phosphatase 5, MKP-5, DUSP10, MKP5
Target/Specificity This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUSP10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP10
Synonyms MKP5
Function Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Detected in brain.
Research Areas
Citations (0)

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Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.


Tanoue, T., et al., J. Biol. Chem. 274(28):19949-19956 (1999).
Theodosiou, A., et al., Oncogene 18(50):6981-6988 (1999).
Martell, K.J., et al., Mol. Cells 8(1):2-11 (1998).
Masuda, K., et al., Cytogenet. Cell Genet. 90 (1-2), 71-74 (2000) (): ().

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$ 295.00
$ 99.00
Cat# AP8453a
(40 western blots)
Availability: In Stock
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