|Application ||WB, IHC-P, E|
|Calculated MW||22149 Da|
|Antigen Region||1-30 aa|
|Other Names||Dual specificity protein phosphatase 13 isoform B, DUSP13B, Dual specificity phosphatase SKRP4, Testis- and skeletal-muscle-specific DSP, DUSP13, DUSP13B, TMDP|
|Target/Specificity||This DUSP13-M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP13-M1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP13-M1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.|
|Tissue Location||Most abundantly expressed in the testis. Also found in the skeletal muscle. Testis-specific (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Dual-specificity phosphatases, a subfamily of protein-tyrosine phosphatases, play important roles in signal transduction, cell cycle progression, and tumor suppression. The cDNA encoding a novel phosphatase, PIR1, phosphatase that interacts with RNA/RNP complex 1. Sequence analysis revealed that the predicted 329-amino acid protein has homology to several dual-specificity phosphatases and contains 2 stretches of arginine-rich sequence similar to those found in some RNA-binding proteins. In vitro, recombinant protein displays protein-tyrosine phosphatase activity and binds directly to RNA.
Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K.Biochem. J. 344:819-825(1999).
Deloukas et al. Nature 429:375-381(2004).
Strausberg et al. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
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