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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPM1F Antibody (N-term)   

PPM1F Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PPM1F Antibody (N-term) AP8459a
    Western blot analysis of anti-PPM1F Pab (Cat. #AP8459a) in mouse liver tissue lysate (35ug/lane). PPM1F(arrow) was detected using the purified Pab.
  • WB - PPM1F Antibody (N-term) AP8459a
    Western blot analysis of PPM1F (arrow) using PPM1F Antibody (N-term) (Cat.#AP8459a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PPM1F gene (Lane 2) (Origene Technologies).
  • IHC-P - PPM1F Antibody (N-term) AP8459a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49593
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49831 Da
Antigen Region 11-40 aa
Additional Information
Gene ID 9647
Other Names Protein phosphatase 1F, Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2, Protein fem-2 homolog, hFem-2, PPM1F, KIAA0015, POPX2
Target/Specificity This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human PPM1F.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPM1F Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1F
Synonyms KIAA0015, POPX2
Function Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
Research Areas
Citations (0)

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PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.


Harvey, B.P., et al., J. Biol. Chem. 279(23):24889-24898 (2004).
Izmailova, E., et al., Nat. Med. 9(2):191-197 (2003).
Koh, C.G., et al., Curr. Biol. 12(4):317-321 (2002).
Tan, K.M., et al., J. Biol. Chem. 276(47):44193-44202 (2001).

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$ 295.00
$ 99.00
Cat# AP8459a
(40 western blots)
Availability: In Stock
Bulk Size
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