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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CTDSP2 Antibody (N-term)   

CTDSP2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CTDSP2 Antibody (N-term) AP8460a
    Western blot analysis of anti-CTDSP2 Antibody (N-term) (Cat.#AP8460a) in mouse lung tissue lysates (35ug/lane). CTDSP2(arrow) was detected using the purified Pab.
  • WB - CTDSP2 Antibody (N-term) AP8460a
    Western blot analysis of anti-CTDSP2 Antibody (N-term) (Cat.#AP8460a) in HepG2 cell line lysates (35ug/lane). hCTDSP2-S27(arrow) was detected using the purified Pab.
  • IHC-P - CTDSP2 Antibody (N-term) AP8460a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • IHC-P - CTDSP2 Antibody (N-term) AP8460a
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CTDSP2 Antibody (N-term) (Cat.#AP8460a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14595
Other Accession Q53ZR2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30664 Da
Antigen Region 12-42 aa
Additional Information
Gene ID 10106
Other Names Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4, SCP2
Target/Specificity This CTDSP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human CTDSP2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTDSP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTDSP2
Synonyms NIF2, OS4, SCP2
Function Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Cellular Location Nucleus.
Tissue Location Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver
Research Areas
Citations (0)

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Background

CTDSP2 is one of several small CTD phosphatases (SCP). It has been proposed that SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. In addition, expression of phosphatase CTDSP2 mRNA isenhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes, and CTDSP2 coamplifies with CDK4 in some primary sarcomas. CTDSP2 may contribute to the development of a subset of sarcomas.

References

Yeo, M., et al., J. Biol. Chem. 278(28):26078-26085 (2003).
Su, Y.A., et al., Oncogene 15(11):1289-1294 (1997).
Beutler, E., et al., Blood Cells Mol. Dis. 21(3):207-216 (1995).
Su, Y.A., et al., Proc. Natl. Acad. Sci. U.S.A. 91(19):9121-9125 (1994).
Su, Y.A., et al., Oncogene 15, 1290-1294 (1997) (): ().

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Cat# AP8460a
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