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PPP3CC Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PPP3CC Antibody (N-term) AP8465a
    Western blot analysis of hPPP3CC-E33 (Cat. #AP8465a) in HL-60, Jurkat, A375 cell line lysates (35ug/lane). PPP3CC (arrow) was detected using the purified Pab.
  • IHC-P - PPP3CC Antibody (N-term) AP8465a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48454
Other Accession PPP3CC
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58129 Da
Antigen Region 18-47 aa
Additional Information
Gene ID 5533
Other Names Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3
Target/Specificity This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human PPP3CC.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPP3CC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CALNA3, CNA3
Function Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Tissue Location Testis.
Research Areas
Citations (0)

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Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).


Eastwood, S.L., et al., Biol. Psychiatry 57(7):702-710 (2005).
Gerber, D.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100(15):8993-8998 (2003).
Bennasser, Y., et al., Virology 303(1):174-180 (2002).
Esau, C., et al., J. Exp. Med. 194(10):1449-1459 (2001).
Muramatsu, T., et al., Biochem. Biophys. Res. Commun. 188(1):265-271 (1992).

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$ 295.00
$ 99.00
Cat# AP8465a
(40 western blots)
Availability: In Stock
Bulk Size
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