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DUSP3 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DUSP3 Antibody (N-term) AP8478a
    Western blot analysis of anti-DUSP3 Pab (Cat. #AP8478a) in SK-BR-3 cell line lysate.DUSP3(arrow) was detected using the purified Pab.
  • WB - DUSP3 Antibody (N-term) AP8478a
    Western blot analysis of DUSP3 (arrow) using rabbit polyclonal DUSP3 Antibody (E6) (Cat. #AP8478a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DUSP3 gene.
  • IHC-P - DUSP3 Antibody (N-term) AP8478a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51452
Other Accession Q9D7X3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20478 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 1845
Other Names Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase, VHR, DUSP3, VHR
Target/Specificity This DUSP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUSP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP3
Synonyms VHR
Function Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Cellular Location Nucleus.
Research Areas
Citations ( 0 )


DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.


Alonso, A., et al., Nat. Immunol. 4(1):44-48 (2003).
Alonso, A., et al., J. Biol. Chem. 276(7):4766-4771 (2001).
Todd, J.L., et al., J. Biol. Chem. 274(19):13271-13280 (1999).
Kamb, A., et al., Genomics 23(1):163-167 (1994).
Folander, K., et al., Genomics 23(1):295-296 (1994).

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$ 295.00
$ 99.00
Cat# AP8478a
(40 western blots)
Availability: In Stock
Bulk Size
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