- CITATIONS: 2
|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||129383 Da|
|Antigen Region||181-210 aa|
|Other Names||Thrombospondin-1, THBS1, TSP, TSP1|
|Target/Specificity||This THBS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the N-terminal region of human THBS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THBS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).|
|Cellular Location||Endoplasmic reticulum. Sarcoplasmic reticulum|
Provided below are standard protocols that you may find useful for product applications.
THBS1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis,and tumorigenesis.
Hofsteenge,J., et.al., J. Biol. Chem. 276 (9), 6485-6498 (2001)
Roszmusz,E., et.al., Biochem. Biophys. Res. Commun. 296 (1), 156-160 (2002)
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