- CITATIONS: 2
|Application ||WB, IHC-P, FC, E|
|Other Accession||P14628, P79182|
|Calculated MW||30748 Da|
|Antigen Region||148-174 aa|
|Other Names||Interleukin-1 beta, IL-1 beta, Catabolin, IL1B, IL1F2|
|Target/Specificity||This IL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.|
|Cellular Location||Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins|
Provided below are standard protocols that you may find useful for product applications.
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
Yu,J., et.al., Am. J. Gastroenterol. (2009)
Ito,A., et.al., J. Biol. Chem. 271 (25), 14657-14660 (1996)
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