- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||16708 Da|
|Antigen Region||30-56 aa|
|Other Names||Natriuretic peptides A, CDD-ANF, Prepronatriodilatin, Cardiodilatin-related peptide, CDP, Atrial natriuretic factor, ANF, Atrial natriuretic peptide, ANP, NPPA, ANP, PND|
|Target/Specificity||This NPPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-56 amino acids from the N-terminal region of human NPPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPPA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.|
Provided below are standard protocols that you may find useful for product applications.
NPPA belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor(containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity.
Watanabe,Y., et.al., Biochem. Mol. Med. 61 (1), 47-51 (1997)
Suga,S., et.al., Endocrinology 130 (1), 229-239 (1992)
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