|Application ||WB, E|
|Calculated MW||47608 Da|
|Antigen Region||325-352 aa|
|Other Names||Actin-related protein 3B, ARP3-beta, Actin-like protein 3B, Actin-related protein ARP4, ACTR3B, ARP11, ARP4|
|Target/Specificity||This ACTR3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the C-terminal region of human ACTR3B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTR3B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection|
|Tissue Location||Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential|
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Provided below are standard protocols that you may find useful for product applications.
ACTR3B plays a role in the organization of the actin cytoskeleton. It may function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks and may decrease the metastatic potential of tumors.
Ewing,R.M., et.al., Mol. Syst. Biol. 3, 89 (2007)
Shindo-Okada,N.et.al., Biochem. Biophys. Res. Commun. 280 (1), 61-67 (2001)
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