|Application ||WB, E|
|Calculated MW||46786 Da|
|Antigen Region||208-237 aa|
|Other Names||Gasdermin-B, Gasdermin-like protein, GSDMB, GSDML|
|Target/Specificity||This GSDMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human GSDMB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GSDMB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells.|
|Cellular Location||Cytoplasm. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells|
|Tissue Location||Expressed in gastric, liver and colon cell lines, carcinomas and non-lesional tissues|
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Provided below are standard protocols that you may find useful for product applications.
GSDMB is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.
Hur,J.W., et.al., Rheumatol. Int. 28 (8), 783-789 (2008)
Chen,M.J., et.al., Nucleic Acids Res. 35 (8), 2682-2694 (2007)
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