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GSDMB Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GSDMB Antibody (Center) AP8559c
    Western blot analysis of GSDMB Antibody (Center) (Cat. #AP8559c) in HL-60, MDA-MB435 cell line lysates (35ug/lane). GSDMB (arrow) was detected using the purified Pab.
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8TAX9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46786 Da
Antigen Region 208-237 aa
Additional Information
Gene ID 55876
Other Names Gasdermin-B, Gasdermin-like protein, GSDMB, GSDML
Target/Specificity This GSDMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human GSDMB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSDMB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSDMB
Synonyms GSDML
Function The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).
Cellular Location Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P57764}. Cell membrane {ECO:0000250|UniProtKB:P57764}. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells
Tissue Location In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach
Research Areas
Citations ( 0 )

Background

GSDMB is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.

References

Hur,J.W., et.al., Rheumatol. Int. 28 (8), 783-789 (2008)
Chen,M.J., et.al., Nucleic Acids Res. 35 (8), 2682-2694 (2007)

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$ 295.00
$ 99.00
Cat# AP8559c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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