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TOB1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TOB1 Antibody (N-term) AP8571a
    Western blot analysis of TOB1 Antibody (N-term) (Cat. #AP8571a) in mouse liver tissue lysates (35ug/lane). TOB1 (arrow) was detected using the purified Pab.
  • IHC-P - TOB1 Antibody (N-term) AP8571a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with TOB1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - TOB1 Antibody (N-term) AP8571a
    TOB1 Antibody (N-term) (Cat. #AP8571a) flow cytometric analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50616
Other Accession Q8R5K6, Q61471
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38155 Da
Antigen Region 54-83 aa
Additional Information
Gene ID 10140
Other Names Protein Tob1, Transducer of erbB-2 1, TOB1, TOB, TROB1
Target/Specificity This TOB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human TOB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTOB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOB1
Synonyms TOB, TROB1
Function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex.
Cellular Location Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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TOB1 is a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.


Suzuki,T.,, Genes Dev. 16 (11), 1356-1370 (2002)
Yoshida,Y.,, Cell 103 (7), 1085-1097 (2000)

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$ 295.00
$ 99.00
Cat# AP8571a
(40 western blots)
Availability: In Stock
Bulk Size
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