|Application ||WB, E|
|Calculated MW||70963 Da|
|Antigen Region||152-180 aa|
|Other Names||Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69|
|Target/Specificity||This ZMYND11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the N-terminal region of human ZMYND11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZMYND11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.|
|Cellular Location||Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes|
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Provided below are standard protocols that you may find useful for product applications.
ZMYND11 is first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression.
Yu,B., Shao,Y., et.al., Exp. Cell Res. 315 (20), 3543-3553 (2009)
Kurozumi,K., et.al., Genes Cells 3 (4), 257-264 (1998)
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