PON3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q15166 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39607 Da |
Antigen Region | 10-38 aa |
Gene ID | 5446 |
---|---|
Other Names | Serum paraoxonase/lactonase 3, PON3 |
Target/Specificity | This PON3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human PON3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PON3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PON3 |
---|---|
Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
Cellular Location | Secreted, extracellular space. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PON3 is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis.
References
Precourt,L.P., et.al., Int. J. Biochem. Cell Biol. 41 (7), 1628-1637 (2009)
Mackness,B., et.al., Curr. Opin. Lipidol. 13 (4), 357-362 (2002)
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