|Application ||WB, IHC-P, FC, E|
|Calculated MW||39607 Da|
|Antigen Region||10-38 aa|
|Other Names||Serum paraoxonase/lactonase 3, PON3|
|Target/Specificity||This PON3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human PON3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PON3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
PON3 is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis.
Precourt,L.P., et.al., Int. J. Biochem. Cell Biol. 41 (7), 1628-1637 (2009)
Mackness,B., et.al., Curr. Opin. Lipidol. 13 (4), 357-362 (2002)
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