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SDH Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8601a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP8601a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SDH Antibody (N-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P21912 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 31630 Da |
SDH Antibody (N-term) - Additional info | |
| Gene ID 6390 | |
| Other Names SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II | |
| Target/Specificity This SDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36~66 amino acids from the N-terminal region of human SDH. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SDH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SDH Antibody (N-term) - Protein Information | |
| Name SDHB | |
| Synonyms SDH, SDH1 | |
| Function Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | |
| Cellular Location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side | |
SDH Antibody (N-term) - Related products
AP8601a: SDH Antibody (N-term)
SDH Antibody (N-term) - Application data
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Western blot analysis of SDH Antibody (N-term) (Cat. #AP8601a) in HL-60 cell line lysates (35ug/lane). SDH (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SDH Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of HepG2 cells using SDH Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
SDH Antibody (N-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme.
REFERENCES
Astuti,D., et.al., Am. J. Hum. Genet. 69 (1), 49-54 (2001) Au,H.C., et.al., Gene 159 (2), 249-253 (1995)
