|Application ||WB, IHC-P, FC, E|
|Calculated MW||25218 Da|
|Antigen Region||140-169 aa|
|Other Names||Vesicle transport through interaction with t-SNAREs homolog 1A, Vesicle transport v-SNARE protein Vti1-like 2, Vti1-rp2, VTI1A|
|Target/Specificity||This VTI1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the C-terminal region of human VTI1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VTI1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.|
|Cellular Location||Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein|
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V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. It may be concerned with increased secretion of cytokines associated with cellular senescence.
Tai,G., et.al., Mol. Biol. Cell 15 (9), 4011-4022 (2004)
Mallard,F., et.al., J. Cell Biol. 156 (4), 653-664 (2002)
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