LMOD1 Antibody (Center N201)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P29536 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67030 Da |
Antigen Region | 214-241 aa |
Gene ID | 25802 |
---|---|
Other Names | Leiomodin-1, 64 kDa autoantigen 1D, 64 kDa autoantigen 1D3, 64 kDa autoantigen D1, Leiomodin, muscle form, Smooth muscle leiomodin, SM-Lmod, Thyroid-associated ophthalmopathy autoantigen, LMOD1 |
Target/Specificity | This LMOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-241 amino acids from the Central region of human LMOD1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LMOD1 Antibody (Center N201) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LMOD1 |
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Function | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. |
Cellular Location | Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A0G2K0D3}. Note=Colocalizes with actin filaments in sarcomeres. {ECO:0000250|UniProtKB:A0A0G2K0D3} |
Tissue Location | Detected in lung vascular smooth muscle (at protein level) (PubMed:27144530). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle (PubMed:2026759). Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine (PubMed:11318603). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks.
References
Zhang,Z.G., et.al., Clin. Immunol. Immunopathol. 80 (3 PT 1), 236-244 (1996)
Conley,C.A.et.al., Curr. Eye Res. 19 (4), 313-322 (1999)
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