|Application ||FC, IHC-P, WB, E|
|Calculated MW||56688 Da|
|Antigen Region||446-477 aa|
|Other Names||Cytochrome P450 2A13, CYPIIA13, CYP2A13|
|Target/Specificity||This CYP2A13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 446-477 amino acids from the C-terminal region of human CYP2A13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP2A13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CYP2A13 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco.
Smith,G., et.al., Xenobiotica 28 (12), 1129-1165 (1998)
Nelson,D.R., et.al., Pharmacogenetics 14 (1), 1-18 (2004)
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