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DSC1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DSC1 Antibody (C-term) AP8666b
    Western blot analysis of DSC1 Antibody (C-term) (Cat. #AP8666b) in A375 cell line lysates (35ug/lane). DSC1 (arrow) was detected using the purified Pab.
  • FC - DSC1 Antibody (C-term) AP8666b
    DSC1 Antibody (C-term) (Cat. #AP8666b) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08554
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99987 Da
Antigen Region 659-687 aa
Additional Information
Gene ID 1823
Other Names Desmocollin-1, Cadherin family member 1, Desmosomal glycoprotein 2/3, DG2/DG3, DSC1, CDHF1
Target/Specificity This DSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-687 amino acids from the C-terminal region of human DSC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDSC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DSC1
Synonyms CDHF1
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome
Tissue Location Strongly expressed in epidermis, less in lymph node and tongue
Research Areas
Citations (0)

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DSC1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined.


Toulza,E.,, Genome Biol. 8 (6), R107 (2007)
Descargues,P.,, J. Invest. Dermatol. 126 (7), 1622-1632 (2006)

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Cat# AP8666b
(40 western blots)
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