|Application ||WB, IHC-P, E|
|Other Accession||Q3SWS9, Q8BVL9, A6QR54|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||73209 Da|
|Antigen Region||270-297 aa|
|Other Names||Janus kinase and microtubule-interacting protein 1, GABA-B receptor-binding protein, Multiple alpha-helices and RNA-linker protein 1, Marlin-1, JAKMIP1, GABABRBP, JAMIP1, MARLIN1|
|Target/Specificity||This JAKMIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-297 amino acids from the Central region of human JAKMIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAKMIP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GABABRBP, JAMIP1, MARLIN1|
|Function||Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.|
|Cellular Location||Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells|
|Tissue Location||Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
JAKMIP1 associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. It may play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Jin,J., et.al., Curr. Biol. 14 (16), 1436-1450 (2004)
Steindler,C., et.al., J. Biol. Chem. 279 (41), 43168-43177 (2004)
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1. Block with 3% skim milk for 1 hour at room temperature. 2. Incubate overnight with Abgent primary antibody 1:1000 in 3% skim milk at 4℃ 3. Wash 5*5 min with TBST. 4. Incubate with HRP-conjugated secondary antibody 1:5000 in 3% skim milk for 1 hour at room temperature. 5. Wash 5*5 min with TBST. 6. Incubate with ECL substrates and expose