|Application ||WB, IHC-P, FC, E|
|Calculated MW||43381 Da|
|Antigen Region||241-269 aa|
|Other Names||1-acyl-sn-glycerol-3-phosphate acyltransferase gamma, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGP acyltransferase 3, 1-AGPAT 3, Lysophosphatidic acid acyltransferase gamma, LPAAT-gamma, AGPAT3, LPAAT3|
|Target/Specificity||This AGPAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the Central region of human AGPAT3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGPAT3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Nucleus envelope|
|Tissue Location||Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.|
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Provided below are standard protocols that you may find useful for product applications.
AGPAT3 is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. This protein may be an integral membrane protein.
Leung,D.W. et.al., Front. Biosci. 6, D944-D953 (2001)
Lu,B., et.al., Biochem. J. 385 (PT 2), 469-477 (2005)
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