|Application ||WB, IHC-P, FC, E|
|Calculated MW||38023 Da|
|Antigen Region||270-300 aa|
|Other Names||Mitochondrial amidoxime reducing component 2, mARC2, 1---, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MARC2, MOSC2|
|Target/Specificity||This MOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the C-terminal region of human MOSC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOSC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.|
|Cellular Location||Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome|
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Provided below are standard protocols that you may find useful for product applications.
Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.
Havemeyer,A., et.al., J. Biol. Chem. 281 (46), 34796-34802 (2006)
Simpson,J.C., et.al.,EMBO Rep. 1 (3), 287-292 (2000)
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