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CNTNAP2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CNTNAP2 Antibody (Center) AP8701c
    Western blot analysis of CNTNAP2 Antibody (Center) (Cat. #AP8701c) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab.
  • IHC-P - CNTNAP2 Antibody (Center) AP8701c
    Formalin-fixed and paraffin-embedded mouse brain tissue reacted with CNTNAP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHC6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 148167 Da
Antigen Region 1079-1106 aa
Additional Information
Gene ID 26047
Other Names Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868
Target/Specificity This CNTNAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1079-1106 amino acids from the Central region of human CNTNAP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCNTNAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CASPR2 {ECO:0000303|PubMed:10624965}, KI
Function May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}
Tissue Location Predominantly expressed in nervous system.
Research Areas
Citations (0)

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CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.


Denisenko-Nehrbass,N.,, Eur. J. Neurosci. 17 (2), 411-416 (2003)
Nakayama,M.,, Genome Res. 12 (11), 1773-1784 (2002)

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Cat# AP8701c
(40 western blots)
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