|Application ||WB, IHC-P, E|
|Other Accession||Q5XI42, E9Q3E1|
|Calculated MW||51840 Da|
|Antigen Region||334-360 aa|
|Other Names||Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase 7, ALDH3B1, ALDH7|
|Target/Specificity||This ALDH3B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-360 amino acids from the Central region of human ALDH3B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH3B1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.|
|Cellular Location||Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm|
|Tissue Location||Highest expression in kidney and lung.|
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Provided below are standard protocols that you may find useful for product applications.
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.
Marchitti,S.A., et.al., Biochem. Biophys. Res. Commun. 356 (3), 792-798 (2007)
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