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DIO2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - DIO2 Antibody (Center) AP8718c
    Western blot analysis of lysates from human heart and human skeletal muscle tissue lysate (from left to right), using DIO2 Antibody (Center)(Cat. #AP8718c). AP8718c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • WB - DIO2 Antibody (Center) AP8718c
    Western blot analysis of DIO2 Antibody (Center) (Cat. #AP8718c) in MCF-7 cell line lysates (35ug/lane). DIO2 (arrow) was detected using the purified Pab.
  • IHC-P - DIO2 Antibody (Center) AP8718c
    DIO2 Antibody (Center) (Cat. #AP8718c) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the mouse DIO2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - DIO2 Antibody (Center) AP8718c
    DIO2 Antibody (Center) (Cat. #AP8718c) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92813
Other Accession Q6QN12
Reactivity Human
Predicted Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30552 Da
Antigen Region 165-191 aa
Additional Information
Gene ID 1734
Other Names Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2
Target/Specificity This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the Central region of human DIO2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDIO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DIO2
Synonyms ITDI2, TXDI2
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Cellular Location Membrane; Single-pass membrane protein
Tissue Location Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain
Research Areas
Citations (0)

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DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3).


He,B.,, Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (6), 986-990 (2009)
Heemstra,K.A.,, J. Clin. Endocrinol. Metab. 94 (6), 2144-2150 (2009)

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$ 295.00
$ 99.00
Cat# AP8718c
(40 western blots)
Availability: In Stock
Bulk Size
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