|Application ||WB, FC, E|
|Calculated MW||36043 Da|
|Antigen Region||86-112 aa|
|Other Names||Melanocortin receptor 3, MC3-R, MC3R|
|Target/Specificity||This MC3R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-112 amino acids from the Central region of human MC3R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MC3R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Brain, placental, and gut tissues.|
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Provided below are standard protocols that you may find useful for product applications.
MC3R is a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy.
Magenis,R.E.,et.al., Mamm. Genome 5 (8), 503-508 (1994)
Konda,Y., et.al., J. Biol. Chem. 269 (18), 13162-13166 (1994)
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