|Application ||WB, FC, E|
|Calculated MW||40495 Da|
|Antigen Region||213-239 aa|
|Other Names||B1 bradykinin receptor, B1R, BK-1 receptor, BDKRB1, BRADYB1|
|Target/Specificity||This BDK_1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-239 amino acids from the Central region of human BDK_1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BDK_1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. BDKRB1 is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
Bachvarov,D.R., et.al., Genomics 33 (3), 374-381 (1996)
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