MPV17 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P39210 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 19733 Da |
Antigen Region | 24-50 aa |
Gene ID | 4358 |
---|---|
Other Names | Protein Mpv17, MPV17 |
Target/Specificity | This MPV17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-50 amino acids from the N-terminal region of human MPV17. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MPV17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MPV17 |
---|---|
Function | Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MPV17 is a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species.
References
Iida,R., et.al., J. Biol. Chem. 278 (8), 6301-6306 (2003)
Karasawa,M., et.al., Hum. Mol. Genet. 2 (11), 1829-1834 (1993)
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