- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||48361 Da|
|Antigen Region||365-391 aa|
|Other Names||D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4|
|Target/Specificity||This DRD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRD4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
Provided below are standard protocols that you may find useful for product applications.
DRD4 is the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.
Livingstone,C.D., et.al., Biochem. J. 287 (PT 1), 277-282 (1992)
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