|Application ||WB, IHC-P, FC, E|
|Other Accession||P24807, NP_037362|
|Calculated MW||8097 Da|
|Antigen Region||1-30 aa|
|Other Names||Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A|
|Target/Specificity||This CD24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CD24.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD24 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
CD24 is a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. This protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
Kay,R., et.al., J. Immunol. 147 (4), 1412-1416 (1991)
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