KCNH2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q12809 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 126655 Da |
Antigen Region | 861-888 aa |
Gene ID | 3757 |
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Other Names | Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv111, KCNH2, ERG, ERG1, HERG |
Target/Specificity | This KCNH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-888 amino acids from the Central region of human KCNH2. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KCNH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KCNH2 |
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Synonyms | ERG, ERG1, HERG |
Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
KCNH2 is a voltage-activated potassium channel belonging to the eag family.
References
Trudeau,M.C., et.al., Science 269 (5220), 92-95 (1995)
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