- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||130848 Da|
|Antigen Region||727-755 aa|
|Other Names||Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, CD49a, ITGA1|
|Target/Specificity||This ITGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 727-755 amino acids from the Central region of human ITGA1.|
|Precautions||ITGA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Provided below are standard protocols that you may find useful for product applications.
ITGA1 is the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
Bank,I., et.al., J. Clin. Immunol. 11 (1), 29-38 (1991)
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