|Application ||WB, FC, IF, E|
|Calculated MW||68478 Da|
|Antigen Region||628-656 aa|
|Other Names||RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS|
|Target/Specificity||This EWSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-656 amino acids from the C-terminal region of human EWSR1.|
|Precautions||EWSR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation|
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Provided below are standard protocols that you may find useful for product applications.
EWSR1 is a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain.
Bhagirath,T., et.al., Genes Chromosomes Cancer 13 (2), 126-132 (1995)
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