|Application ||WB, IHC-P, FC, E|
|Calculated MW||55084 Da|
|Antigen Region||6-33 aa|
|Other Names||Ubiquitin-associated protein 1, UBAP-1, Nasopharyngeal carcinoma-associated gene 20 protein, UBAP1|
|Target/Specificity||This UBAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human UBAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.|
|Cellular Location||Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic Recruited to endosomes as part of the ESCRT-I complex|
|Tissue Location||Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
UBAP1 is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein riginates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas.
Qian,J., et.al., J. Cancer Res. Clin. Oncol. 127 (10), 613-618 (2001) Qian,J., et.al., Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 33 (2), 147-152 (2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.