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COL18A1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P39060 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 178188 Da |
| Antigen Region | 237-263 aa |
| Gene ID | 80781 |
|---|---|
| Other Names | Collagen alpha-1(XVIII) chain, Endostatin, COL18A1 |
| Target/Specificity | This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-263 amino acids from the N-terminal region of human COL18A1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COL18A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COL18A1 (HGNC:2195) |
|---|---|
| Function | Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061} [Endostatin]: Secreted. Secreted, extracellular space, extracellular matrix, basement membrane |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Present in multiple organs with highest levels in liver, lung and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
COL18A1 is encoding the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein.
References
Fu,Y.,et.al., Biochemistry 48 (49), 11655-11663 (2009)
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