|Application ||WB, IHC-P, FC, E|
|Other Accession||P40146, P97490|
|Calculated MW||140122 Da|
|Antigen Region||946-972 aa|
|Other Names||Adenylate cyclase type 8, ATP pyrophosphate-lyase 8, Adenylate cyclase type VIII, Adenylyl cyclase 8, AC8, Ca(2+)/calmodulin-activated adenylyl cyclase, ADCY8|
|Target/Specificity||This ADCY8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 946-972 amino acids from the Central region of human ADCY8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Detected in brain cortex.|
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Provided below are standard protocols that you may find useful for product applications.
ADCY8 is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase provided by RefSeq].
Martin,A.C.,et.al., Mol. Pharmacol. 75 (4), 830-842 (2009)
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