|Application ||WB, IHC-P, FC, E|
|Calculated MW||67258 Da|
|Antigen Region||56-83 aa|
|Other Names||E3 ubiquitin-protein ligase DTX4, 632-, Protein deltex-4, Deltex4, RING finger protein 155, DTX4, KIAA0937, RNF155|
|Target/Specificity||This DTX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human DTX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DTX4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.|
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Provided below are standard protocols that you may find useful for product applications.
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations
Storck,S.,et.al., Mol. Cell. Biol. 25 (4), 1437-1445 (2005)
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