|Application ||WB, E|
|Other Accession||P49799, Q0R4E4, Q4R525, Q29RM9|
|Predicted||Rat, Rabbit, Monkey, Bovine|
|Calculated MW||23256 Da|
|Antigen Region||147-174 aa|
|Other Names||Regulator of G-protein signaling 4, RGP4, RGS4, RGS4|
|Target/Specificity||This RGS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the Central region of human RGS4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.|
|Tissue Location||Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum|
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Provided below are standard protocols that you may find useful for product applications.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.
Heximer,S.P., et.al., Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14389-14393 (1997)
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