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RGS4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RGS4 Antibody (Center) AP8879c
    Western blot analysis of RGS4 Antibody (Center) (Cat. #AP8879c) in MDA-MB231 cell line lysates (35ug/lane). RGS4 (arrow) was detected using the purified Pab.
  • WB - RGS4 Antibody (Center) AP8879c
    Western blot analysis of RGS4 Antibody (Center) (Cat. #AP8879c) in mouse brain tissue lysates (35ug/lane). RGS4 (arrow) was detected using the purified Pab.
  • WB - RGS4 Antibody (Center) AP8879c
    Western blot analysis of RGS4 (arrow) using rabbit polyclonal RGS4 Antibody (Center) (Cat. #AP8879c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RGS4 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49798
Other Accession P49799, Q0R4E4, Q4R525, Q29RM9
Reactivity Human, Mouse
Predicted Rat, Rabbit, Monkey, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23256 Da
Antigen Region 147-174 aa
Additional Information
Gene ID 5999
Other Names Regulator of G-protein signaling 4, RGP4, RGS4, RGS4
Target/Specificity This RGS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the Central region of human RGS4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRGS4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS4
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Tissue Location Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum
Research Areas
Citations (0)

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Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.


Heximer,S.P.,, Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14389-14393 (1997)

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Cat# AP8879c
(40 western blots)
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