INPP4B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, IHC-P, E |
---|---|
Primary Accession | O15327 |
Other Accession | Q9QWG5, Q6P1Y8, Q4R4D7 |
Reactivity | Human |
Predicted | Monkey, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 104738 Da |
Antigen Region | 367-393 aa |
Gene ID | 8821 |
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Other Names | Type II inositol 3, 4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type II, INPP4B |
Target/Specificity | This INPP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-393 amino acids from the Central region of human INPP4B. |
Dilution | WB~~1:500 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | INPP4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INPP4B |
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Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). |
Tissue Location | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
INPP4B catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.
References
Norris F.A., et.al., J. Biol. Chem. 272:23859-23864(1997).
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