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INPP4B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - INPP4B Antibody (Center) AP8902c
    Anti-INPP4B Antibody (Center) at 1:500 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 105 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • IHC-P - INPP4B Antibody (Center) AP8902c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with INPP4B Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - INPP4B Antibody (Center) AP8902c
    INPP4B Antibody (Center) (Cat. #AP8902c) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IHC-P, E
Primary Accession O15327
Other Accession Q9QWG5, Q6P1Y8, Q4R4D7
Reactivity Human
Predicted Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 104738 Da
Antigen Region 367-393 aa
Additional Information
Gene ID 8821
Other Names Type II inositol 3, 4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type II, INPP4B
Target/Specificity This INPP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-393 amino acids from the Central region of human INPP4B.
Dilution WB~~1:500
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsINPP4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INPP4B
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).
Tissue Location Widely expressed with highest levels occurring in the skeletal muscle and heart.
Research Areas
Citations (0)
citation

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Background

INPP4B catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

References

Norris F.A., et.al., J. Biol. Chem. 272:23859-23864(1997).

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$ 365.00
$ 140.00
Cat# AP8902c
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