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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   UNC13B Antibody (Center)   

UNC13B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UNC13B Antibody (Center) AP8905c
    Western blot analysis of UNC13B Antibody (Center) (Cat. #AP8905c) in 293 cell line lysates (35ug/lane). UNC13B (arrow) was detected using the purified Pab.
  • FC - UNC13B Antibody (Center) AP8905c
    UNC13B Antibody (Center) (Cat. #AP8905c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession O14795
Other Accession Q9Z1N9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 180679 Da
Antigen Region 1062-1091 aa
Additional Information
Gene ID 10497
Other Names Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Target/Specificity This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUNC13B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13B
Synonyms UNC13
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).
Tissue Location Expressed in kidney cortical epithelial cells and brain.
Research Areas
Citations ( 0 )

Background

UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).

References

Sjoeblom T., et.al., Science 314:268-274(2006).
Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).

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$ 295.00
$ 99.00
Cat# AP8905c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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