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UNC13B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UNC13B Antibody (Center) AP8905c
    Western blot analysis of UNC13B Antibody (Center) (Cat. #AP8905c) in 293 cell line lysates (35ug/lane). UNC13B (arrow) was detected using the purified Pab.
    detail
  • FC - UNC13B Antibody (Center) AP8905c
    UNC13B Antibody (Center) (Cat. #AP8905c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession O14795
Other Accession Q9Z1N9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 180679 Da
Antigen Region 1062-1091 aa
Additional Information
Gene ID 10497
Other Names Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Target/Specificity This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUNC13B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13B (HGNC:12566)
Synonyms UNC13
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity)
Tissue Location Expressed in kidney cortical epithelial cells and brain.
Research Areas
Citations ( 0 )

Background

UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).

References

Sjoeblom T., et.al., Science 314:268-274(2006).
Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).

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$ 365.00
$ 140.00
Cat# AP8905c
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