- CITATIONS: 2
|Application ||WB, IHC-P, FC, E|
|Calculated MW||135167 Da|
|Antigen Region||1066-1095 aa|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, 3424-, ADAMTS18, ADAMTS21|
|Target/Specificity||This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 amino acids from the C-terminal region of human ADAMTS18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||ADAMTS18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium|
Provided below are standard protocols that you may find useful for product applications.
ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.
Zeng,W., et.al., Biochim. Biophys. Acta 1760 (3), 517-524 (2006)
Jin,H., et.al., Oncogene 26 (53), 7490-7498 (2007)
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