|Application ||WB, FC, E|
|Other Accession||Q32NP8, Q9PVZ3, Q9DE25, Q61572|
|Predicted||Mouse, Zebrafish, Xenopus|
|Calculated MW||56789 Da|
|Antigen Region||488-515 aa|
|Other Names||Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3, FOXC1, FKHL7, FREAC3|
|Target/Specificity||This FOXC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 488-515 amino acids from the C-terminal region of human FOXC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOXC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.|
|Tissue Location||Expressed in all tissues and cell lines examined.|
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Provided below are standard protocols that you may find useful for product applications.
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
Mears,A.J., et.al., Am. J. Hum. Genet. 59 (6), 1321-1327 (1996)
Gould,D.B., et.al., Am. J. Hum. Genet. 61 (3), 765-768 (1997)
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