|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||54009 Da|
|Antigen Region||179-210 aa|
|Other Names||Glucagon receptor, GL-R, GCGR|
|Target/Specificity||This GCGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FOXC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCGR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
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