|Application ||WB, E|
|Calculated MW||41497 Da|
|Antigen Region||41-69 aa|
|Other Names||Ceroid-lipofuscinosis neuronal protein 5, Protein CLN5, CLN5|
|Target/Specificity||This CLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human CLN5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLN5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).|
|Cellular Location||Ceroid-lipofuscinosis neuronal protein 5, secreted form: Lysosome|
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Provided below are standard protocols that you may find useful for product applications.
CLN5 responsible likely is involved in the degradation of post-translationally modified proteins in lysosomes.
Savukoski,M., et.al., Am. J. Hum. Genet. 55 (4), 695-701 (1994)
Mole,S.E., et.al., Hum. Mutat. 14 (3), 199-215 (1999)
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