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CLN5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75503 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41497 Da |
| Antigen Region | 41-69 aa |
| Gene ID | 1203 |
|---|---|
| Other Names | Ceroid-lipofuscinosis neuronal protein 5, Protein CLN5, CLN5 |
| Target/Specificity | This CLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human CLN5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLN5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLN5 |
|---|---|
| Synonyms | BMPS {ECO:0000303|PubMed:37708259} |
| Function | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG) (PubMed:37708259). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis (PubMed:37708259). Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths (PubMed:37708259). Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane (PubMed:22431521). Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521). |
| Cellular Location | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome |
| Tissue Location | Ubiquitous.. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
CLN5 responsible likely is involved in the degradation of post-translationally modified proteins in lysosomes.
References
Savukoski,M., et.al., Am. J. Hum. Genet. 55 (4), 695-701 (1994)
Mole,S.E., et.al., Hum. Mutat. 14 (3), 199-215 (1999)
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$ 365.00
$ 140.00
Cat# AP8914a
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