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CLN5 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLN5 Antibody (N-term) AP8914a
    Western blot analysis of CLN5 Antibody (N-term) (Cat. #AP8914a) in T47D cell line lysates (35ug/lane).CLN5 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75503
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41497 Da
Antigen Region 41-69 aa
Additional Information
Gene ID 1203
Other Names Ceroid-lipofuscinosis neuronal protein 5, Protein CLN5, CLN5
Target/Specificity This CLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human CLN5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLN5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLN5
Function Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).
Cellular Location Ceroid-lipofuscinosis neuronal protein 5, secreted form: Lysosome
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

CLN5 responsible likely is involved in the degradation of post-translationally modified proteins in lysosomes.

References

Savukoski,M., et.al., Am. J. Hum. Genet. 55 (4), 695-701 (1994)
Mole,S.E., et.al., Hum. Mutat. 14 (3), 199-215 (1999)

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$ 295.00
$ 99.00
Cat# AP8914a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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