|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8K4K3, Q5GLH2, NP_067675|
|Calculated MW||38801 Da|
|Antigen Region||1-30 aa|
|Other Names||Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)|
|Target/Specificity||This TRIB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||TRIB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.|
|Tissue Location||Highly expressed in peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)
Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
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