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TRIB2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRIB2 Antibody (N-term) AP8930a
    Western blot analysis of TRIB2 (arrow) using rabbit polyclonal TRIB2 N-term (Cat. #AP8930a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRIB2 gene (Lane 2) .
  • IHC-P - TRIB2 Antibody (N-term) AP8930a
    TRIB2 Antibody (N-term) (Cat. #AP8930a) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TRIB2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - TRIB2 Antibody (N-term) AP8930a
    TRIB2 Antibody (N-term) (Cat. #AP8930a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92519
Other Accession Q8K4K3, Q5GLH2, NP_067675
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38801 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 28951
Other Names Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Target/Specificity This TRIB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIB2 (HGNC:30809)
Function Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.
Tissue Location Highly expressed in peripheral blood leukocytes.
Research Areas
Citations (0)

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TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.


Hegele,R.A.,, Hum. Mol. Genet. 18 (21), 4189-4194 (2009)
Eder,K.,, Int. Immunol. 20 (12), 1543-1550 (2008)

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Cat# AP8930a
(40 western blots)
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