|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8K4K3, Q5GLH2, NP_067675|
|Calculated MW||38801 Da|
|Antigen Region||1-30 aa|
|Other Names||Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)|
|Target/Specificity||This TRIB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.|
|Tissue Location||Highly expressed in peripheral blood leukocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)
Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.