|Application ||WB, E|
|Other Accession||P47973, P22893|
|Calculated MW||34003 Da|
|Antigen Region||116-142 aa|
|Other Names||Tristetraprolin, TTP, G0/G1 switch regulatory protein 24, Growth factor-inducible nuclear protein NUP475, Protein TIS11A, TIS11, Zinc finger protein 36 homolog, Zfp-36, ZFP36, G0S24, RNF162A, TIS11A, TTP|
|Target/Specificity||This ZFP36 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-142 amino acids from the Central region of human ZFP36.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZFP36 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||G0S24, RNF162A, TIS11A, TTP|
|Function||mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ZFP36 is probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Has been experimentally shown to be able to bind zinc.
Lee,H.H., et.al., Int. J. Cancer 126 (8), 1817-1827 (2010)
Datta,S., eet.al., J. Immunol. 184 (3), 1484-1491 (2010)
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