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ACMSD Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8954a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP8954a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ACMSD Antibody (N-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | Q8TDX5 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 38035 Da |
ACMSD Antibody (N-term) - Additional info | |
| Gene ID 130013 | |
| Other Names ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase | |
| Target/Specificity This ACMSD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46~75 amino acids from the N-terminal region of human ACMSD. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACMSD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACMSD Antibody (N-term) - Protein Information | |
| Name ACMSD | |
| Function Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway | |
ACMSD Antibody (N-term) - Related products
AP8954a: ACMSD Antibody (N-term)
RI10060: ACMSD predesign siRNA
DC04250: Human ACMSD cDNA Clone
ACMSD Antibody (N-term) - Application data
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Western blot analysis of ACMSD Antibody (N-term) (Cat. #AP8954a) in mouse kidney tissue lysates (35ug/lane). ACMSD (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human brain tissue reacted with ACMSD Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ACMSD Antibody (N-term) (Cat. #AP8954a) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ACMSD Antibody (N-term) - Research Areas
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BACKGROUND
ACMSD is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS).ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
REFERENCES
Garavaglia,S., et.al., FEBS J. 276 (22), 6615-6623 (2009) Fukuoka,S., et.al., J. Biol. Chem. 277 (38), 35162-35167 (2002)
